Interleukin-1R Signaling Is Essential for Induction of Proapoptotic CD8 T Cells, Viral Clearance, and Pathology during Lymphocytic Choriomeningitis Virus Infection in Mice

The T cell granule exocytosis pathway is essential to control hepatotropic lymphocytic choriomeningitis virus strain WE (LCMV-WE) but also contributes to the observed pathology in mice. Although effective antiviral T cell immunity and development of viral hepatitis are strictly dependent on perforin...

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Detalhes bibliográficos
Main Authors: Joeckel, Lars T., Wallich, Reinhard, Metkar, Sunil S., Froelich, Christopher J., Simon, Markus M., Borner, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421753/
https://ncbi.nlm.nih.gov/pubmed/22674984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00682-12
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