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Effect of Rifampin and Rifabutin on the Pharmacokinetics of Lersivirine and Effect of Lersivirine on the Pharmacokinetics of Rifabutin and 25-O-Desacetyl-Rifabutin in Healthy Subjects

Lersivirine is a nonnucleoside reverse transcriptase inhibitor (NNRTI) with a unique resistance profile exhibiting potent antiviral activity against wild-type HIV and several clinically relevant NNRTI-resistant strains. Lersivirine, a weak inducer of the cytochrome P450 (CYP) enzyme CYP3A4, is metab...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Vourvahis, Manoli, Davis, John, Wang, Rong, Layton, Gary, Choo, Heng Wee, Chong, Chew-Lan, Tawadrous, Margaret
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2012
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421562/
https://ncbi.nlm.nih.gov/pubmed/22644026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06282-11
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