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The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells

Dynamic interactions between intracellular networks regulate cellular homeostasis and responses to perturbations. Targeted therapy is aimed at perturbing oncogene addiction pathways in cancer, however, development of acquired resistance to these drugs is a significant clinical problem. A network-bas...

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Detalhes bibliográficos
Main Authors: Komurov, Kakajan, Tseng, Jen-Te, Muller, Melissa, Seviour, Elena G, Moss, Tyler J, Yang, Lifeng, Nagrath, Deepak, Ram, Prahlad T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421441/
https://ncbi.nlm.nih.gov/pubmed/22864381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2012.25
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