Chronic Hypoxia during Gestation Causes Epigenetic Repression of ERα Gene in Ovine Uterine Arteries via Heightened Promoter Methylation

Estrogen receptor α (ERα) plays a key role in the adaptation of increased uterine blood flow in pregnancy. Chronic hypoxia is a common stress to maternal cardiovascular homeostasis and causes increased risk of preeclampsia. Studies in pregnant sheep demonstrated that hypoxia during gestation downreg...

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Bibliographic Details
Main Authors: Dasgupta, Chiranjib, Chen, Man, Zhang, Haitao, Yang, Shumei, Zhang, Lubo
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421058/
https://ncbi.nlm.nih.gov/pubmed/22777938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.198242
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