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Activity Dependent Degeneration Explains Hub Vulnerability in Alzheimer's Disease
Brain connectivity studies have revealed that highly connected ‘hub’ regions are particularly vulnerable to Alzheimer pathology: they show marked amyloid-β deposition at an early stage. Recently, excessive local neuronal activity has been shown to increase amyloid deposition. In this study we use a...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3420961/ https://ncbi.nlm.nih.gov/pubmed/22915996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002582 |
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