Activity Dependent Degeneration Explains Hub Vulnerability in Alzheimer's Disease

Brain connectivity studies have revealed that highly connected ‘hub’ regions are particularly vulnerable to Alzheimer pathology: they show marked amyloid-β deposition at an early stage. Recently, excessive local neuronal activity has been shown to increase amyloid deposition. In this study we use a...

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Autori principali: de Haan, Willem, Mott, Katherine, van Straaten, Elisabeth C. W., Scheltens, Philip, Stam, Cornelis J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420961/
https://ncbi.nlm.nih.gov/pubmed/22915996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002582
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