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A quantitative quasispecies theory-based model of virus escape mutation under immune selection

Viral infections involve a complex interplay of the immune response and escape mutation of the virus quasispecies inside a single host. Although fundamental aspects of such a balance of mutation and selection pressure have been established by the quasispecies theory decades ago, its implications hav...

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Detalhes bibliográficos
Main Authors: Woo, Hyung-June, Reifman, Jaques
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420195/
https://ncbi.nlm.nih.gov/pubmed/22826258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117201109
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