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Polygenic Effects of Common Single-Nucleotide Polymorphisms on Life Span: When Association Meets Causality

Recently we have shown that the human life span is influenced jointly by many common single-nucleotide polymorphisms (SNPs), each with a small individual effect. Here we investigate further the polygenic influence on life span and discuss its possible biological mechanisms. First we identified six s...

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Bibliographische Detailangaben
Hauptverfasser: Yashin, Anatoliy I., Wu, Deqing, Arbeev, Konstantin G., Ukraintseva, Svetlana V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419841/
https://ncbi.nlm.nih.gov/pubmed/22533364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/rej.2011.1257
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