CYP2C19 polymorphism affects single-dose pharmacokinetics of oral pantoprazole in healthy volunteers

OBJECTIVES: Pantoprazole is metabolized by cytochrome P450 2 C19, which shows genetic polymorphism. The effect of CYP2C19 polymorphism on single-dose pharmacokinetics of oral pantoprazole in healthy volunteers was evaluated. METHODS: Pantoprazole pharmacokinetics was determined in 32 healthy volunte...

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Bibliographic Details
Main Authors: Gawrońska-Szklarz, Barbara, Adamiak-Giera, Urszula, Wyska, Elżbieta, Kurzawski, Mateusz, Gornik, Wanda, Kaldonska, Maria, Drozdzik, Marek
Format: Artigo
Language:Inglês
Published: Springer-Verlag 2012
Subjects:
Pharmacogenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419350/
https://ncbi.nlm.nih.gov/pubmed/22418828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-012-1252-3
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