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Statistical tests for detecting rare variants using variance-stabilizing transformations
Next generation sequencing holds great promise for detecting rare variants underlying complex human traits. Due to their extremely low allele frequencies, the normality approximation for a proportion no longer works well. The Fisher’s exact method appears to be suitable but it is conservative. We in...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3418475/ https://ncbi.nlm.nih.gov/pubmed/22724536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-1809.2012.00718.x |
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