Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10

Antagonists of human growth hormone-releasing hormone (hGHRH) with increased potency and improved enzymatic and chemical stability are needed for potential clinical applications. We synthesized 21 antagonistic analogs of hGHRH(1-29)NH(2), substituted at positions 8, 9, and 10 of the common core sequ...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Varga, Jozsef L., Schally, Andrew V., Horvath, Judit E., Kovacs, Magdolna, Halmos, Gabor, Groot, Kate, Toller, Gabor L., Rekasi, Zoltan, Zarandi, Marta
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2004
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC341828/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14755056/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307288101
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