Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10

Antagonists of human growth hormone-releasing hormone (hGHRH) with increased potency and improved enzymatic and chemical stability are needed for potential clinical applications. We synthesized 21 antagonistic analogs of hGHRH(1-29)NH(2), substituted at positions 8, 9, and 10 of the common core sequ...

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Bibliografiske detaljer
Main Authors: Varga, Jozsef L., Schally, Andrew V., Horvath, Judit E., Kovacs, Magdolna, Halmos, Gabor, Groot, Kate, Toller, Gabor L., Rekasi, Zoltan, Zarandi, Marta
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC341828/
https://ncbi.nlm.nih.gov/pubmed/14755056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307288101
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