Stem Cell Microvesicles Transfer Cystinosin to Human Cystinotic Cells and Reduce Cystine Accumulation In Vitro

Cystinosis is a rare disease caused by homozygous mutations of the CTNS gene, encoding a cystine efflux channel in the lysosomal membrane. In Ctns knockout mice, the pathologic intralysosomal accumulation of cystine that drives progressive organ damage can be reversed by infusion of wildtype bone ma...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Iglesias, Diana M., El-Kares, Reyhan, Taranta, Anna, Bellomo, Francesco, Emma, Francesco, Besouw, Martine, Levtchenko, Elena, Toelen, Jaan, van den Heuvel, Lambertus, Chu, LeeLee, Zhao, Jing, Young, Yoon Kow, Eliopoulos, Nicoletta, Goodyer, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418268/
https://ncbi.nlm.nih.gov/pubmed/22912749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042840
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados