Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity

Retinoic acid inducible gene I (RIG-I)-like receptors (RLRs) function as cytoplasmic sensors for viral RNA to initiate antiviral responses including type I interferon (IFN) production. It has been unclear how RIG-I encounters and senses viral RNA. To address this issue, we examined intracellular loc...

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Hlavní autoři: Onomoto, Koji, Jogi, Michihiko, Yoo, Ji-Seung, Narita, Ryo, Morimoto, Shiho, Takemura, Azumi, Sambhara, Suryaprakash, Kawaguchi, Atushi, Osari, Suguru, Nagata, Kyosuke, Matsumiya, Tomoh, Namiki, Hideo, Yoneyama, Mitsutoshi, Fujita, Takashi
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418241/
https://ncbi.nlm.nih.gov/pubmed/22912779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043031
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