Virus-Infection or 5′ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1

In virus-infected cells, RIG-I-like receptor (RLR) recognizes cytoplasmic viral RNA and triggers innate immune responses including production of type I and III interferon (IFN) and the subsequent expression of IFN-inducible genes. Interferon-β promoter stimulator 1 (IPS-1, also known as MAVS, VISA a...

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Main Authors: Onoguchi, Kazuhide, Onomoto, Koji, Takamatsu, Shiori, Jogi, Michihiko, Takemura, Azumi, Morimoto, Shiho, Julkunen, Ilkka, Namiki, Hideo, Yoneyama, Mitsutoshi, Fujita, Takashi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908619/
https://ncbi.nlm.nih.gov/pubmed/20661427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001012
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