Characterization of the mechanism of protection mediated by CS-D7, a monoclonal antibody to Staphylococcus aureus iron regulated surface determinant B (IsdB)

We previously reported the development of a human monoclonal antibody (CS-D7, IgG(1)) with specificity and affinity for the iron regulated surface determinant B (IsdB) of Staphylococcus aureus. CS-D7 mediates opsonophagocytic killing in vitro and protection in a murine sepsis model. In light of rece...

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Detalhes bibliográficos
Main Authors: Pancari, Gregory, Fan, Hongxia, Smith, Sharon, Joshi, Amita, Haimbach, Robin, Clark, Desmond, Li, Yingzhe, Hua, Jin, McKelvey, Troy, Ou, Yangsi, Drummond, James, Cope, Leslie, Montgomery, Donna, McNeely, Tessie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2012
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417506/
https://ncbi.nlm.nih.gov/pubmed/22919628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2012.00036
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