Pharmacological activity of a Bv8 analogue modified in position 24

BACKGROUND AND PURPOSE: The amphibian peptide Bv8 induces potent nociceptive sensitization in rodents. Its mammalian homologue, prokineticin 2 (PROK2), is strongly up-regulated in inflamed tissues and is a major determinant in triggering inflammatory pain. Bv8 and PROK2 activate two closely related...

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Autors principals: Lattanzi, R, Sacerdote, P, Franchi, S, Canestrelli, M, Miele, R, Barra, D, Visentin, S, DeNuccio, C, Porreca, F, De Felice, M, Guida, F, Luongo, L, de Novellis, V, Maione, S, Negri, L
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2012
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417421/
https://ncbi.nlm.nih.gov/pubmed/22122547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01797.x
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