Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals

BACKGROUND AND PURPOSE: Chemokines are involved in neuroinflammation and contribute to chronic pain processing. The new chemokine prokineticin 2 (PROK2) and its receptors (PKR(1) and PKR(2)) have a role in inflammatory pain and immunomodulation. In the present study, we investigated the involvement...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Maftei, D, Marconi, V, Florenzano, F, Giancotti, L A, Castelli, M, Moretti, S, Borsani, E, Rodella, L F, Balboni, G, Luongo, L, Maione, S, Sacerdote, P, Negri, L, Lattanzi, R
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294109/
https://ncbi.nlm.nih.gov/pubmed/24902717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12793
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