The SLCO1B1*5 Genetic Variant is Associated with Statin-Induced Side Effects

OBJECTIVES: Identify SNPs associated with mild statin-induced side effects. BACKGROUND: Statin-induced side effects can interfere with therapy. SNPs in cytochrome P450 enzymes impair statin metabolism; the reduced function SLCO1B1*5 allele impairs statin clearance and is associated with simvastatin-...

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Bibliografiske detaljer
Main Authors: Voora, Deepak, Shah, Svati H., Spasojevic, Ivan, Ali, Shazia, Reed, Carol R., Salisbury, Benjamin A., Ginsburg, Geoffrey S.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417133/
https://ncbi.nlm.nih.gov/pubmed/19833260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2009.04.053
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