Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells

DNA ligase I (LigI) plays a central role in the joining of strand interruptions during replication and repair. In our current study, we provide evidence that DNA ligase III (LigIII) and XRCC1, which form a complex that functions in single-strand break repair, are required for the proliferation of ma...

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Detalhes bibliográficos
Main Authors: Le Chalony, Catherine, Hoffschir, Françoise, Gauthier, Laurent R., Gross, Julia, Biard, Denis S., Boussin, François D., Pennaneach, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: SP Birkhäuser Verlag Basel 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417097/
https://ncbi.nlm.nih.gov/pubmed/22460582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-012-0975-8
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