Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death

Functional telomeres are protected from non-homologous end-joining (NHEJ) and homologous recombination (HR) DNA repair pathways. Replication is a critical period for telomeres because of the requirement for reconstitution of functional protected telomere conformations, a process that involves DNA re...

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Main Authors: Gauthier, Laurent R., Granotier, Christine, Hoffschir, Françoise, Etienne, Olivier, Ayouaz, Ali, Desmaze, Chantal, Mailliet, Patrick, Biard, Denis S., Boussin, François D.
Formato: Artigo
Idioma:Inglês
Publicado: SP Birkhäuser Verlag Basel 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265728/
https://ncbi.nlm.nih.gov/pubmed/21773671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-011-0767-6
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