Structurally Modified Curcumin Analogs Inhibit STAT3 Phosphorylation and Promote Apoptosis of Human Renal Cell Carcinoma and Melanoma Cell Lines

The Janus kinase-2 (Jak2)-signal transducer and activator of transcription-3 (STAT3) pathway is critical for promoting an oncogenic and metastatic phenotype in several types of cancer including renal cell carcinoma (RCC) and melanoma. This study describes two small molecule inhibitors of the Jak2-ST...

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Detalhes bibliográficos
Main Authors: Bill, Matthew A., Nicholas, Courtney, Mace, Thomas A., Etter, Jonathan P., Li, Chenglong, Schwartz, Eric B., Fuchs, James R., Young, Gregory S., Lin, Li, Lin, Jiayuh, He, Lei, Phelps, Mitch, Li, Pui-Kai, Lesinski, Gregory B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416819/
https://ncbi.nlm.nih.gov/pubmed/22899991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040724
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