Phase 1 dose-ranging study of ezatiostat hydrochloride in combination with lenalidomide in patients with non-deletion (5q) low to intermediate-1 risk myelodysplastic syndrome (MDS)

BACKGROUND: Ezatiostat, a glutathione S-transferase P1-1 inhibitor, promotes the maturation of hematopoietic progenitors and induces apoptosis in cancer cells. RESULTS: Ezatiostat was administered to 19 patients with non-deletion(5q) myelodysplastic syndrome (MDS) at one of two doses (2000 mg or 250...

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Detalhes bibliográficos
Main Authors: Raza, Azra, Galili, Naomi, Mulford, Deborah, Smith, Scott E, Brown, Gail L, Steensma, David P, Lyons, Roger M, Boccia, Ralph, Sekeres, Mikkael A, Garcia-Manero, Guillermo, Mesa, Ruben A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416694/
https://ncbi.nlm.nih.gov/pubmed/22546242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-5-18
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