Crystal structure of a new benzoic acid inhibitor of influenza neuraminidase bound with a new tilt induced by overpacking subsite C6

BACKGROUND: Influenza neuraminidase (NA) is an important target for antiviral inhibitors since its active site is highly conserved such that inhibitors can be cross-reactive against multiple types and subtypes of influenza. Here, we discuss the crystal structure of neuraminidase subtype N9 complexed...

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Hlavní autoři: Venkatramani, Lalitha, Johnson, Eric S, Kolavi, Gundurao, Air, Gillian M, Brouillette, Wayne J, Mooers, Blaine HM
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416664/
https://ncbi.nlm.nih.gov/pubmed/22559154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-12-7
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