Pyrrolidinobenzoic Acid Inhibitors of Influenza Virus Neuraminidase: the Hydrophobic Side Chain Influences Type A Subtype Selectivity

Neuraminidase (NA) plays a critical role in the life cycle of influenza virus and is a target for new therapeutic agents. A series of influenza neuraminidase inhibitors with the pyrrolidinobenzoic acid scaffold containing lipophilic side chains at the C3 position have been synthesized and evaluated...

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Bibliografiset tiedot
Päätekijät: Li, Yanwu, Silamkoti, Arundutt, Kolavi, Gundurao, Mou, Liyuan, Gulati, Shelly, Air, Gillian M., Brouillette, Wayne J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401542/
https://ncbi.nlm.nih.gov/pubmed/22677529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.001
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