Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct

BACKGROUND: RNA interference (RNAi) has been used as a promising approach to inhibit human immunodeficiency virus type 1 (HIV-1) replication for both in vitro and in vivo animal models. However, HIV-1 escape mutants after RNAi treatment have been reported. Expressing multiple small interfering RNAs...

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Bibliographic Details
Main Authors:	Zhang, Tao, Cheng, Tong, Wei, Lihua, Cai, Yijun, Yeo, Anthony Et, Han, Jiahuai, Yuan, Y Adam, Zhang, Jun, Xia, Ningshao
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2012
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3416660/ https://ncbi.nlm.nih.gov/pubmed/22709537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-9-118
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Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct

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