The Dominant-Negative Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR Increases the Efficacy of Rift Valley Fever Virus MP-12 Vaccine

Rift Valley fever virus (RVFV), belonging to the genus Phlebovirus, family Bunyaviridae, is endemic to sub-Saharan Africa and causes a high rate of abortion in ruminants and hemorrhagic fever, encephalitis, or blindness in humans. MP-12 is the only RVFV strain excluded from the select-agent rule and...

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Main Authors: Lihoradova, Olga, Kalveram, Birte, Indran, Sabarish V., Lokugamage, Nandadeva, Juelich, Terry L., Hill, Terence E., Tseng, Chien-Te K., Gong, Bin, Fukushi, Shuetsu, Morikawa, Shigeru, Freiberg, Alexander N., Ikegami, Tetsuro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416293/
https://ncbi.nlm.nih.gov/pubmed/22573861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00778-12
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