Corneal Replication Is an Interferon Response-Independent Bottleneck for Virulence of Herpes Simplex Virus 1 in the Absence of Virion Host Shutoff

Herpes simplex viruses lacking the virion host shutoff function (Δvhs) are avirulent and hypersensitive to type I and type II interferon (IFN). In this study, we demonstrate that even in the absence of IFN responses in AG129 (IFN-αβγR(−/−)) mice, Δvhs remains highly attenuated via corneal infection...

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Bibliographic Details
Main Authors: Pasieka, Tracy Jo, Menachery, Vineet D., Rosato, Pamela C., Leib, David A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416281/
https://ncbi.nlm.nih.gov/pubmed/22553331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00761-12
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