HIV-1 gp120 Vaccine Induces Affinity Maturation in both New and Persistent Antibody Clonal Lineages

Most antibodies that broadly neutralize HIV-1 are highly somatically mutated in antibody clonal lineages that persist over time. Here, we describe the analysis of human antibodies induced during an HIV-1 vaccine trial (GSK PRO HIV-002) that used the clade B envelope (Env) gp120 of clone W6.1D (gp120...

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Main Authors: Moody, M. Anthony, Yates, Nicole L., Amos, Joshua D., Drinker, Mark S., Eudailey, Joshua A., Gurley, Thaddeus C., Marshall, Dawn J., Whitesides, John F., Chen, Xi, Foulger, Andrew, Yu, Jae-Sung, Zhang, Ruijun, Meyerhoff, R. Ryan, Parks, Robert, Scull, Julia Cavanaugh, Wang, Lu, Vandergrift, Nathan A., Pickeral, Joy, Pollara, Justin, Kelsoe, Garnett, Alam, S. Munir, Ferrari, Guido, Montefiori, David C., Voss, Gerald, Liao, Hua-Xin, Tomaras, Georgia D., Haynes, Barton F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416280/
https://ncbi.nlm.nih.gov/pubmed/22553329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00426-12
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