H3N2 Influenza Infection Elicits More Cross-Reactive and Less Clonally Expanded Anti-Hemagglutinin Antibodies Than Influenza Vaccination

BACKGROUND: During the recent H1N1 influenza pandemic, excess morbidity and mortality was seen in young but not older adults suggesting that prior infection with influenza strains may have protected older subjects. In contrast, a history of recent seasonal trivalent vaccine in younger adults was not...

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Main Authors: Moody, M. Anthony, Zhang, Ruijun, Walter, Emmanuel B., Woods, Christopher W., Ginsburg, Geoffrey S., McClain, Micah T., Denny, Thomas N., Chen, Xi, Munshaw, Supriya, Marshall, Dawn J., Whitesides, John F., Drinker, Mark S., Amos, Joshua D., Gurley, Thaddeus C., Eudailey, Joshua A., Foulger, Andrew, DeRosa, Katherine R., Parks, Robert, Meyerhoff, R. Ryan, Yu, Jae-Sung, Kozink, Daniel M., Barefoot, Brice E., Ramsburg, Elizabeth A., Khurana, Surender, Golding, Hana, Vandergrift, Nathan A., Alam, S. Munir, Tomaras, Georgia D., Kepler, Thomas B., Kelsoe, Garnett, Liao, Hua-Xin, Haynes, Barton F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198447/
https://ncbi.nlm.nih.gov/pubmed/22039424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025797
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