Intermolecular Binding between TIFA-FHA and TIFA-pT Mediates Tumor Necrosis Factor Alpha Stimulation and NF-κB Activation

The forkhead-associated (FHA) domain recognizes phosphothreonine (pT) with high specificity and functional diversity. TIFA (TRAF-interacting protein with an FHA domain) is the smallest FHA-containing human protein. Its overexpression was previously suggested to provoke NF-κB activation, yet its exac...

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Detalhes bibliográficos
Main Authors: Huang, Chia-Chi Flora, Weng, Jui-Hung, Wei, Tong-You Wade, Wu, Pei-Yu Gabriel, Hsu, Pang-Hung, Chen, Yu-Hou, Wang, Shun-Chang, Qin, Dongyan, Hung, Chin-Chun, Chen, Shui-Tsung, Wang, Andrew H.-J., Shyy, John Y.-J., Tsai, Ming-Daw
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416184/
https://ncbi.nlm.nih.gov/pubmed/22566686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00438-12
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