Glycosylation of Simian Immunodeficiency Virus Influences Immune-Tissue Targeting during Primary Infection, Leading to Immunodeficiency or Viral Control

Glycans of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) play pivotal roles in modulating virus-target cell interactions. We have previously reported that, whereas SIVmac239 is pathogenic, its deglycosylated essentially nonpathogenic mutant (Δ5G) serves as a live-attenua...

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Autors principals: Sugimoto, Chie, Nakamura, Shinichiro, Hagen, Shoko I., Tsunetsugu-Yokota, Yasuko, Villinger, Francois, Ansari, Aftab A., Suzuki, Yasuo, Yamamoto, Naoki, Nagai, Yoshiyuki, Picker, Louis J., Mori, Kazuyasu
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416168/
https://ncbi.nlm.nih.gov/pubmed/22718828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00948-12
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