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PD-1–Mediated Attrition of Polyfunctional Memory CD8(+) T Cells in Chronic Toxoplasma Infection
We reported earlier that during chronic toxoplasmosis CD8(+) T cells become functionally exhausted with concomitant PD-1 upregulation, leading to eventual host mortality. However, how immune exhaustion specifically mediates attrition of CD8 polyfunctionality, a hallmark of potent T-cell response, du...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3415930/ https://ncbi.nlm.nih.gov/pubmed/22539813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis304 |
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