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CD40-CD40L pathway plays a critical CD8 intrinsic and extrinsic role during rescue of exhausted CD8 T cells
CD8 exhaustion mediated by inhibitory PD-1-PD-L1 pathway occurs in several chronic infections including toxoplasmosis. While blockade of PD-1-PD-L1 pathway revives this response, the role of co-stimulatory receptors involved in this rescue has not been ascertained in any model of CD8 exhaustion. Thi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3197960/ https://ncbi.nlm.nih.gov/pubmed/21949017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102319 |
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