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Targeting Pan-Resistant Bacteria With Antibodies to a Broadly Conserved Surface Polysaccharide Expressed During Infection

BACKGROUND: New therapeutic targets for antibiotic-resistant bacterial pathogens are desperately needed. The bacterial surface polysaccharide poly-β-(1-6)-N-acetyl-glucosamine (PNAG) mediates biofilm formation by some bacterial species, and antibodies to PNAG can confer protective immunity. By analy...

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Main Authors: Skurnik, David, Davis, Michael R., Benedetti, Dennis, Moravec, Katie L., Cywes-Bentley, Colette, Roux, Damien, Traficante, David C., Walsh, Rebecca L., Maira-Litràn, Tomas, Cassidy, Sara K., Hermos, Christina R., Martin, Thomas R., Thakkallapalli, Erin L., Vargas, Sara O., McAdam, Alexander J., Lieberman, Tami D., Kishony, Roy, LiPuma, John J., Pier, Gerald B., Goldberg, Joanna B., Priebe, Gregory P.
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2012
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415848/
https://ncbi.nlm.nih.gov/pubmed/22448004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis254
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