Targeting Pan-Resistant Bacteria With Antibodies to a Broadly Conserved Surface Polysaccharide Expressed During Infection

BACKGROUND: New therapeutic targets for antibiotic-resistant bacterial pathogens are desperately needed. The bacterial surface polysaccharide poly-β-(1-6)-N-acetyl-glucosamine (PNAG) mediates biofilm formation by some bacterial species, and antibodies to PNAG can confer protective immunity. By analy...

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Autors principals: Skurnik, David, Davis, Michael R., Benedetti, Dennis, Moravec, Katie L., Cywes-Bentley, Colette, Roux, Damien, Traficante, David C., Walsh, Rebecca L., Maira-Litràn, Tomas, Cassidy, Sara K., Hermos, Christina R., Martin, Thomas R., Thakkallapalli, Erin L., Vargas, Sara O., McAdam, Alexander J., Lieberman, Tami D., Kishony, Roy, LiPuma, John J., Pier, Gerald B., Goldberg, Joanna B., Priebe, Gregory P.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Major Articles and Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415848/
https://ncbi.nlm.nih.gov/pubmed/22448004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis254
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