Targeting Pan-Resistant Bacteria With Antibodies to a Broadly Conserved Surface Polysaccharide Expressed During Infection

BACKGROUND: New therapeutic targets for antibiotic-resistant bacterial pathogens are desperately needed. The bacterial surface polysaccharide poly-β-(1-6)-N-acetyl-glucosamine (PNAG) mediates biofilm formation by some bacterial species, and antibodies to PNAG can confer protective immunity. By analy...

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Detalhes bibliográficos
Main Authors: Skurnik, David, Davis, Michael R., Benedetti, Dennis, Moravec, Katie L., Cywes-Bentley, Colette, Roux, Damien, Traficante, David C., Walsh, Rebecca L., Maira-Litràn, Tomas, Cassidy, Sara K., Hermos, Christina R., Martin, Thomas R., Thakkallapalli, Erin L., Vargas, Sara O., McAdam, Alexander J., Lieberman, Tami D., Kishony, Roy, LiPuma, John J., Pier, Gerald B., Goldberg, Joanna B., Priebe, Gregory P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415848/
https://ncbi.nlm.nih.gov/pubmed/22448004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis254
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