Targeting Pan-Resistant Bacteria With Antibodies to a Broadly Conserved Surface Polysaccharide Expressed During Infection

BACKGROUND: New therapeutic targets for antibiotic-resistant bacterial pathogens are desperately needed. The bacterial surface polysaccharide poly-β-(1-6)-N-acetyl-glucosamine (PNAG) mediates biofilm formation by some bacterial species, and antibodies to PNAG can confer protective immunity. By analy...

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書誌詳細
主要な著者: Skurnik, David, Davis, Michael R., Benedetti, Dennis, Moravec, Katie L., Cywes-Bentley, Colette, Roux, Damien, Traficante, David C., Walsh, Rebecca L., Maira-Litràn, Tomas, Cassidy, Sara K., Hermos, Christina R., Martin, Thomas R., Thakkallapalli, Erin L., Vargas, Sara O., McAdam, Alexander J., Lieberman, Tami D., Kishony, Roy, LiPuma, John J., Pier, Gerald B., Goldberg, Joanna B., Priebe, Gregory P.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2012
主題:
Major Articles and Brief Reports
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415848/
https://ncbi.nlm.nih.gov/pubmed/22448004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis254
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