Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer

Continued androgen receptor (AR) signaling is an established mechanism underlying castration-resistant prostate cancer (CRPC), and suppression of AR signaling remains a therapeutic goal of CRPC therapy. Constitutively active androgen receptor splice variants (AR-Vs) lack the AR ligand-binding domain...

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Autores principales: Hu, Rong, Lu, Changxue, Mostaghel, Elahe A., Yegnasubramanian, Srinivasan, Gurel, Meltem, Tannahill, Clare, Edwards, Joanne, Isaacs, William, Nelson, Peter S., Bluemn, Eric, Plymate, Stephen R., Luo, Jun
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415705/
https://ncbi.nlm.nih.gov/pubmed/22710436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3892
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