Field and action potential recordings in heart slices: correlation with established in vitro and in vivo models

BACKGROUND AND PURPOSE: Action potential (AP) recordings in ex vivo heart preparations constitute an important component of the preclinical cardiac safety assessment according to the ICH S7B guideline. Most AP measurement models are sensitive, predictive and informative but suffer from a low through...

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Detaylı Bibliyografya
Asıl Yazarlar: Himmel, Herbert M, Bussek, Alexandra, Hoffmann, Michael, Beckmann, Rolf, Lohmann, Horst, Schmidt, Matthias, Wettwer, Erich
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Publishing Ltd 2012
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415654/
https://ncbi.nlm.nih.gov/pubmed/22074238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01775.x
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