Field and action potential recordings in heart slices: correlation with established in vitro and in vivo models

BACKGROUND AND PURPOSE: Action potential (AP) recordings in ex vivo heart preparations constitute an important component of the preclinical cardiac safety assessment according to the ICH S7B guideline. Most AP measurement models are sensitive, predictive and informative but suffer from a low through...

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Detalhes bibliográficos
Main Authors: Himmel, Herbert M, Bussek, Alexandra, Hoffmann, Michael, Beckmann, Rolf, Lohmann, Horst, Schmidt, Matthias, Wettwer, Erich
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415654/
https://ncbi.nlm.nih.gov/pubmed/22074238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01775.x
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