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Adaptive mutations that prevent cross-talk enable the expansion of paralogous signaling protein families
Orthologous proteins often harbor numerous substitutions, but whether these differences result from neutral or adaptive processes is usually unclear. To tackle this challenge, we examined the divergent evolution of a model bacterial signaling pathway comprising the kinase PhoR and its cognate substr...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3415470/ https://ncbi.nlm.nih.gov/pubmed/22770222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.05.033 |
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