Nuclear translocation of the cytoplasmic domain of HB-EGF induces gastric cancer invasion

BACKGROUND: Membrane-anchored heparin-binding epidermal growth factor-like growth factor (proHB-EGF) yields soluble HB-EGF, which is an epidermal growth factor receptor (EGFR) ligand, and a carboxy-terminal fragment of HB-EGF (HB-EGF-CTF) after ectodomain shedding. We previously reported that HB-EGF...

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Bibliographic Details
Main Authors: Shimura, Takaya, Yoshida, Michihiro, Fukuda, Shinji, Ebi, Masahide, Hirata, Yoshikazu, Mizoshita, Tsutomu, Tanida, Satoshi, Kataoka, Hiromi, Kamiya, Takeshi, Higashiyama, Shigeki, Joh, Takashi
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414754/
https://ncbi.nlm.nih.gov/pubmed/22646534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-205
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