PDX-1 Is a Therapeutic Target for Pancreatic Cancer, Insulinoma and Islet Neoplasia Using a Novel RNA Interference Platform

Pancreatic and duodenal homeobox-1 (PDX-1) is a transcription factor that regulates insulin expression and islet maintenance in the adult pancreas. Our recent studies demonstrate that PDX-1 is an oncogene for pancreatic cancer and is overexpressed in pancreatic cancer. The purpose of this study was...

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Autores principales: Liu, Shi-He, Rao, Donald D., Nemunaitis, John, Senzer, Neil, Zhou, Guisheng, Dawson, David, Gingras, Marie-Claude, Wang, Zhaohui, Gibbs, Richard, Norman, Michael, Templeton, Nancy S., DeMayo, Francesco J., O'Malley, Bert, Sanchez, Robbi, Fisher, William E., Brunicardi, F. Charles
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414490/
https://ncbi.nlm.nih.gov/pubmed/22905092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040452
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