C1B domain peptide of protein kinase Cγ significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis

Two peptides derived from the C1B domain of protein kinase Cγ (PKCγ) were shown to associate with classical PKC isozymes and modulate their activities. These C1B peptides are designated C1B1 (amino acid residues 101–112) and C1B5 (residues 141–151). Since PKC enzyme activity is shown to be involved...

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Main Authors: Kawabata, Atsushi, Matsuzuka, Takaya, Doi, Chiyo, Seiler, Garret, Reischman, Jennifer, Pickel, Lara, Ayuzawa, Rie, Nguyen, Thu A., Tamura, Masaaki
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414411/
https://ncbi.nlm.nih.gov/pubmed/22785210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.20840
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