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Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo

The effect of SN-38 was evaluated on multiple lung cancer cell lines. It inhibits anchorage-dependent and –independent growth as monitored by MTT and soft agar colony assay, respectively. SN-38 collapsed the mitochondrial membrane potential (MMP), arrested cells in S- and G2-phases of the cell cycle...

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Detalhes bibliográficos
Main Authors: Maurya, Dharmendra Kumar, Ayuzawa, Rie, Doi, Chiyo, Troyer, Deryl, Tamura, Masaaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133571/
https://ncbi.nlm.nih.gov/pubmed/21609311
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