Isocitrate dehydrogenase 1R132H mutation in microglia/macrophages in gliomas: Indication of a significant role of microglia/macrophages in glial tumorigenesis

Somatic mutation of Isocitrate dehydrogenase 1 (IDH1) at the locus of R132 (IDH1(R132H)) occurs in > 70% of WHO grade II-III gliomas and secondary glioblastomas. To date it remains unknown whether the mutation is restricted to glial tumor cells. Microglial cells are the resident macrophages in th...

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Detalhes bibliográficos
Main Authors: Zheng, Ping-Pin, van der Weiden, Marcel, van der Spek, Peter J., Vincent, Arnaud J.P.E., Kros, Johan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414408/
https://ncbi.nlm.nih.gov/pubmed/22785212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.20836
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