Bufalin-loaded mPEG-PLGA-PLL-cRGD nanoparticles: preparation, cellular uptake, tissue distribution, and anticancer activity

BACKGROUND: Recent studies have shown that bufalin has a good antitumor effect but has high toxicity, poor water solubility, a short half-life, a narrow therapeutic window, and a toxic dose that is close to the therapeutic dose, which all limit its clinical application. This study aimed to determine...

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Bibliographic Details
Main Authors: Yin, Peihao, Wang, Yan, Qiu, YanYan, Hou, LiLi, Liu, Xuan, Qin, Jianmin, Duan, Yourong, Liu, Peifeng, Qiu, Ming, Li, Qi
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2012
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414086/
https://ncbi.nlm.nih.gov/pubmed/22888239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S32063
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