Biodegradable Nanoparticles of mPEG-PLGA-PLL Triblock Copolymers as Novel Non-Viral Vectors for Improving siRNA Delivery and Gene Silencing

Degradation of mRNA by RNA interference is one of the most powerful and specific mechanisms for gene silencing. However, insufficient cellular uptake and poor stability have limited its usefulness. Here, we report efficient delivery of siRNA via the use of biodegradable nanoparticles (NPs) made from...

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Main Authors: Du, Jing, Sun, Ying, Shi, Qiu-Sheng, Liu, Pei-Feng, Zhu, Ming-Jie, Wang, Chun-Hui, Du, Lian-Fang, Duan, You-Rong
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International (MDPI) 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269702/
https://ncbi.nlm.nih.gov/pubmed/22312268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms13010516
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