Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells

Recently, thioridazine (10-[2-(1-methyl-2-piperidyl) ethyl]-2-methylthiophenothiazine), a well-known anti-psychotic agent was found to have anti-cancer activity in cancer cells. However, the molecular mechanism of the agent in cellular signal pathways has not been well defined. Thioridazine signific...

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Bibliographic Details
Main Authors: Kang, Sokbom, Dong, Seung Myung, Kim, Boh-Ram, Park, Mi Sun, Trink, Barry, Byun, Hyun-Jung, Rho, Seung Bae
Format: Artigo
Language:Inglês
Published: Springer US 2012
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413814/
https://ncbi.nlm.nih.gov/pubmed/22460505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-012-0717-2
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