An AnkyrinG-Binding Motif Is Necessary and Sufficient for Targeting Na(v)1.6 Sodium Channels to Axon Initial Segments and Nodes of Ranvier

Neurons are highly polarized cells with functionally distinct axonal and somatodendritic compartments. Voltage-gated sodium channels Na(v)1.2 and Na(v)1.6 are highly enriched at axon initial segments (AISs) and nodes of Ranvier, where they are necessary for generation and propagation of action poten...

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Auteurs principaux: Gasser, Andreas, Ho, Tammy Szu-Yu, Cheng, Xiaoyang, Chang, Kae-Jiun, Waxman, Stephen G., Rasband, Matthew N., Dib-Hajj, Sulayman D.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2012
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413458/
https://ncbi.nlm.nih.gov/pubmed/22623668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5434-11.2012
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