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The transition in spliceosome assembly from complex E to complex A purges surplus U1 snRNPs from alternative splice sites

Spliceosomes are assembled in stages. The first stage forms complex E, which is characterized by the presence of U1 snRNPs base-paired to the 5′ splice site, components recognizing the 3′ splice site and proteins thought to connect them. The splice sites are held in close proximity and the pre-mRNA...

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Библиографические подробности
Главные авторы: Hodson, Mark J., Hudson, Andrew J., Cherny, Dmitry, Eperon, Ian C.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
Предметы:
RNA
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413131/
https://ncbi.nlm.nih.gov/pubmed/22505580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks322
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