Identification of high-confidence somatic mutations in whole genome sequence of formalin-fixed breast cancer specimens

The utilization of archived, formalin-fixed paraffin-embedded (FFPE) tumor samples for massive parallel sequencing has been challenging due to DNA damage and contamination with normal stroma. Here, we perform whole genome sequencing of DNA isolated from two triple-negative breast cancer tumors archi...

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Detalhes bibliográficos
Main Authors: Yost, Shawn E., Smith, Erin N., Schwab, Richard B., Bao, Lei, Jung, HyunChul, Wang, Xiaoyun, Voest, Emile, Pierce, John P., Messer, Karen, Parker, Barbara A., Harismendy, Olivier, Frazer, Kelly A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413110/
https://ncbi.nlm.nih.gov/pubmed/22492626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks299
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