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Phosphoproteomic Analysis of Leukemia Cells under Basal and Drug-treated Conditions Identifies Markers of Kinase Pathway Activation and Mechanisms of Resistance

Protein kinase signaling is fundamental to cell homeostasis and is deregulated in all cancers but varies between patients. Understanding the mechanisms underlying this heterogeneity is critical for personalized targeted therapies. Here, we used a recently established LC-MS/MS platform to profile pro...

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מידע ביבליוגרפי
Main Authors: Alcolea, Maria P., Casado, Pedro, Rodríguez-Prados, Juan-Carlos, Vanhaesebroeck, Bart, Cutillas, Pedro R.
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Biochemistry and Molecular Biology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412974/
https://ncbi.nlm.nih.gov/pubmed/22547687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.017483
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